a dermatological view
ACD in 24 white female volunteers. In
the ICD study, 1.25% SLS patches were
applied to the forearms of volunteers,
followed by twice daily application
of the cream for 14 days. Researchers
observed significantly improved TEWL
in SLS-damaged skin, leading to a
complete recovery on day 15, compared
with the untreated site.
Preventing glove-induced ICD: Zhai
et al. evaluated the ability of a model
lipid emulsion to protect against glove-induced ICD. The test emulsion was
applied to one hand while the opposite
hand remained untreated. After 30 min,
both hands were gloved for 3 hr. Skin
conditions were evaluated by visual
scoring, water sorption-desorption test,
TEWL measurement and skin capacitance. This procedure was repeated
for five days. Emulsion-treated hands
showed significantly greater water holding capacity and lower TEWL values
than untreated hands. Researchers concluded that the test emulsion minimized
glove-induced ICD.
Dexpanthenol skin protection: Biro
et al. investigated the efficacy of dexpanthenol to protect against irritation in a
randomized, prospective, double-blind,
placebo-controlled study. Twenty-five
healthy volunteers were treated on the
inner aspect of both forearms with a
formulation containing 5% dexpanthenol or a placebo twice daily for 26 days.
From days 15 to 22, 2% SLS was applied
to these areas twice daily. Assessments
included sebumetry, corneometry, pH
value and clinical appearance (
photographs). Researchers concluded that
dexpanthenol exhibits protective effects
against skin irritation.
Evaluating irritancy potential and
efficacy: Diepgen et al. compared six
commercially available skin care products with two standard experimental
designs: the chamber scarification test to
assess irritancy potential, and the ROIT,
which was developed to evaluate the efficacy of skin care creams. Results showed
that a high score in the chamber scarification test for skin irritation was not
necessarily correlated to the products’
ability to impede SLS-induced irritant
skin reactions. Three products exhibited
low irritancy potential and were capable
of reducing skin barrier damage induced
by SLS while one product showed both
irritant potential on scarified skin and
also a modest capability to reduce skin
irritation induced by SLS.
not demonstrate a protective function
(e.g., similar to the untreated site), while
beeswax and white petrolatum were
significant in their efficacy to protect
barrier function.
Milk, cream and ointment protection: Ortonne and Queille-Roussel
performed a single-center, blinded, randomized, controlled study in 20 healthy
Caucasian women. During the irritation
period, SLS at 5% was used to induce
skin irritation on both forearms of each
subject daily for five days. A milk (w/o
emulsion), cream (w/o emulsion) and
ointment (water-free emulsion)e were
applied twice daily to three of the four
test sites on days 1–5. The fourth site
served as a control.
The cream was comprised of: water
(aqua), caprylic/capric triglyceride,
polyglyceryl-3 diisostearate, glycerin,
dicaprylyl ether, cetearyl ethylhexanoate,
petrolatum, Cera alba, sodium lactate,
e Dardia Lipo Cream, Lipo Milk and Lipo
Ointment are products manufactured by Intendis
GmbH, Berlin.
Vol. 126, No. 3/March 2011
www.CosmeticsandToiletries.com Cosmetics & Toiletries® magazine | 161
